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"The mice performed less well when we slowed down the treadmill, and this happened at time scales of a few seconds,” Albergaria said.After identifying a causal link between running speeds and associative learning in the cerebellum, the researchers were curious to pinpoint where this enhancement was taking place within the “little brain.” For this phase of their study, the research team used optogenetics to stimulate specific neurons that project to the cerebellum called “mossy fibers.” Within the cerebellum, sensory information is relayed from mossy fibers to granule cells in a way that allows a single mossy fiber axon to influence a huge number of Purkinje cells.
Country: AU GENDER: F State: City: Perth Email | Send Flirt | Add to Favorites About me: I am looking for a guy that likes to have fun and just want to have sex. I'm married to a wonderful husband but i caught my husband cheating on me..."We don't know whether this is true for other, non cerebellar, kinds of learning,” Albergaria cautions.According to Albergaria, "The cerebellum is a well-conserved structure across species and there are circuits that are common across species." She speculates that future research based on these findings could help us better understand how locomotion influences associative learning in the human cerebellum.Interestingly, when the researchers stimulated the mossy fibers using optogenetics, they observed enhanced learning on par with faster running speeds.Therefore, the researchers speculate that finding ways to directly stimulate mossy fiber activity might have the same benefits on associative learning as running.It would be interesting to see if this holds for humans, for cerebellar forms of learning — and even for other types of learning," Carey said in a statement.
The authors conclude, “Our results suggest that locomotor activity modulates delay eyeblink conditioning through increased activation of the mossy fiber pathway within the cerebellum.
Faster treadmill running speeds enhance associative learning in the cerebellum of mice, according to a new study by researchers at the Champalimaud Center for the Unknown.
This paper, “Locomotor Activity Modulates Associative Learning in Mouse Cerebellum,” was published on April 16 in the journal Nature Neuroscience.
Taken together, these results provide evidence for a novel role for behavioral state modulation in associative learning and suggest a potential mechanism through which engaging in movement can improve an individual’s ability to learn.” Future research in the Carey Lab will try to answer bigger questions, such as why walking and other types of aerobic exercise seem to help us coordinate thoughts, organize ideas, and come up with creative solutions.
Anectodal evidence also links physical activity with "Aha! For example, Albert Einstein famously said of E = mc, "I thought of that while riding my bicycle." Along this same line, Manish Saggar of Stanford University has found f MRI brain imaging evidence that enhanced cerebellum connectivity boosts creative capacity.
The mice in this study who had their treadmills set at a faster speed learned to associate the flash of light (which normally doesn’t cause mice to blink) with a puff of air more quickly.